In interstitial photodynamic therapy (I-PDT), image-based preplanning is employed to compute optimal laser fiber configuration on complex tumor shape. Unfortunately, tumor deformation during the I-PDT procedure may have negative impact on the actual light dose delivery. This paper presents a case study of locally advanced head-and-neck cancer (LAHNC). Light propagation modeling on the non-deformed and deformed LAHNC is used to characterize the potential treatment degradation due to tumor deformation. A computational method of calculating deformed tumor shape by tracking implanted fiducial markers is described, which helps bridge the gap between geometric model in preplanning and actual deformed shape.
Ye Han, Emily Oakley, Gal Shafirstein, Yoed Rabin, Levent Burak Kara. (2017). A Compututational Case Study for the Treatment of Head-and-Neck Tumor Using Interstitial Photodynamic Therapy. 5th International Conference on Computational and Mathematical Biomedical Engineering. Pittsburgh, USA, April 10-12, 2017.